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The causes are multiple: metabolic changes, sleep disruption from GI symptoms, and changes in energy metabolism that affect sleep architecture

After the initial reduction in appetite, the food intake of the experimental groups increased to the same amount as the rats in the control group, however, both the high dose and low dose groups were seen to have maintained a lower level of body weight despite the increase in calories

the nephropathy indication followed in 2024: ~24% risk reduction for nephropathy progression and combined kidney/cardiovascular death

Am J Clin Nutr 99:408422

Freezing is particularly damaging to GLP-1 medications

Once I lost the first huge chunk of weight, it was easier for me to move around