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Here are some conditions where you may need B12 shots: You have vitamin B12 deficiency or pernicious anemia

But, how often depends on how bad the deficiency is and how well theyre doing

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Injections allow the body to absorb Vitamin B12 without it having to go through the digestive system like oral tablets

Patients who avoid animal foods, have a limited diet, or live with certain gut conditions are more at risk