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10.1016/j.biomaterials.2023.122037 Biomaterials

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Experimental procedure included 20L as injection volume with a flow rate of 0.7 mL/min, ESI negative ionization, a dwell time of 50 ms, and MRM transitions

Table of Contents The evolution of GLP-1 therapy into chronic treatment Gastrointestinal tolerability beyond three years Discontinuation trends and persistence patterns Strategies for maintaining long-term GLP-1 safety Clinical implications for chronic therapy The Evolution of GLP-1 Therapy Into Chronic Treatment In the early years of incretin-based therapy, clinicians often viewed GLP-1 receptor agonists as add-on treatments for patients with uncontrolled type 2 diabetes