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Oncogene 24 , 17381748 (2005)
In contrast, pathological stimulation involved cyclic stretch at 5% or 20% strain at 1 Hz frequency for 20 h in normoxia (21% O 2 ) and in hypoxia (1% O 2 ) combined with 20% cyclic stretch and exposure to NPs
Naturally present in our bodies, this powerhouse antioxidant supports an even, radiant complexion and helps prevent premature signs of aging triggered by everyday stressors
These phosphorylated Smad2 and Smad3 then interact with their co-chaperone Smad4 to form a complex that reaches the nucleus and stimulates the transcription of pro-fibrotic genes[48]
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