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Mechanism of Action Comparison# Retatrutide# Retatrutide (LY3437943) is a 39-amino acid synthetic peptide that simultaneously activates three metabolically important receptors: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite through hypothalamic and brainstem signaling GIP receptor : Potentiates insulin secretion, may improve beta-cell survival, and contributes to adipose tissue metabolism and central appetite regulation Glucagon receptor : Increases hepatic energy expenditure, promotes fatty acid oxidation in the liver, stimulates thermogenesis in brown adipose tissue, and enhances lipolysis The glucagon receptor component is the defining innovation

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In a statement, a LifeVantage spokesperson wrote that the company has multiple approaches to ensure that our Consultants the companys term for its distributors make legal, truthful and not misleading product claims, including a policy that prohibits unauthorized personal testimonials and any claim that LifeVantage products are useful in the cure, treatment, diagnosis, mitigation or prevention of any diseases or signs or symptoms of disease. The company works to educate its representatives and to take action against problematic pitches, the statement said

Lancet Diabetes Endocrinol 2020;8:903-14.ArticlePubMed 90