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Asia or the Middle East, access to and the use of GLP1-RAs are primarily driven by whether the patient can afford it

The dose of fentanyl we chose for this study (75 g/kg, IV) elicited a robust decrease in minute ventilation (approximately 50% over a period of at least 60 min) and so represents a substantial level of ventilatory impairment by which to examine the effects of the 100 mol/kg dose of GSHee

Mechanistically, 16S rRNA sequencing and untargeted metabolomics revealed that dysbiosis-driven perturbation of the gutbacterialhost lipid axis elevates LD accumulation in hippocampal microglia, increases ceramide levels, and triggers maladaptive neuroimmune responses

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Scrambled siRNA was used as a control

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