Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (often 1.5-2.5 percentage points, depending on dose) and significant weight loss (approximately 5-20% of baseline body weight, with higher percentages generally seen in non-diabetic populations with obesity)
Results vary from person to person, and intermittent fasting isn't appropriate for everyone
PMID: 30424557 Valko, M
Center for Medicare & Medicaid Services
Serious adverse effects requiring immediate medical attention include: Severe abdominal pain that may indicate pancreatitis (inflammation of the pancreas) Persistent nausea and vomiting leading to dehydration Changes in vision or eye pain (particularly in patients with type 2 diabetes and pre-existing retinopathy) Signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness) Symptoms of gallbladder disease (upper right abdominal pain, fever, jaundice) Severe allergic reactions (rash, difficulty breathing, swelling) These medications carry a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though there is no definitive evidence of this risk in humans
requires daily injections compared to weekly with others