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Exenatide may still serve a role in cost-constrained settings or when newer agents are unavailable, but semaglutide is the clear standard of care for new GLP-1 agonist prescriptions

Mitochondrial-derived peptides (MDPs), encoded by mitochondrial DNA (mtDNA) sORFs, include potent metabolic regulators like MOTS-c (16 aa), which activates AMPK to enhance glucose metabolism and oxidative stress resistance 32 , and Humanin (24 aa), a cytoprotective agent that suppresses apoptosis by inhibiting BAX 33

[cited 2021 Jul 08]

It is a synthetic 39-amino-acid molecule that activates three metabolic receptors GIP, GLP-1, and glucagon through one compound

It is used to help lower blood sugar levels when diet and exercise alone are not enough

And finally, reduced ALFF, which implies a significant decrease in local activity