A time-dependent increase could be observed which was more pronounced in the targeted nanocarriers groups
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These include the following: therapeutic benefits resulting from non-antioxidant mechanisms, insufficient dosage to elicit an antioxidant effect, poor oral bioavailability, a narrow therapeutic index, or toxicity that precludes clinical use
Still, the exact processes behind these effects are poorly understood, and studies in humans are limited
While murine models suggest atrial GLP-1R expression, the precise cardiac cell types expressing GLP-1R, especially in humans, are yet to be conclusively identified [33]
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