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Most patients describe this as mild to moderate in severity, occurring primarily during the first few weeks of treatment or after dose increases
A 15 to 30-minute warm-up at room temperature before injection reduces discomfort and ensures smoother delivery
Alternatively, nonstimulant medications are available
The authors suggest that maintaining extremely large weight losses may be harder biologically
Another major point once again involves the amount of weight that could be regained once you cease taking Ozempic
So, taking steps to build and maintain muscle mass is important while taking GLP-1s
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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