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El intervalo mnimo de 4 semanas entre aumentos de dosis permite que el sistema gastrointestinal se adapte progresivamente, reduciendo significativamente la incidencia y severidad de efectos secundarios como nuseas, vmitos y diarrea
still, their effectiveness is limited, and no therapeutic strategy is able to fully stop OA progression
Across the first few months the overall trend for most people is downward, with each dose level a little easier to tolerate than the adjustment period before it, so that by the time someone reaches a maintenance dose day to day nausea is usually infrequent
has had numerous contacts with the pharmaceutical industry and has been a member of advisory boards and given paid lectures
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
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