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[12] According to a patent, "Short duration safety studies with dihexa have uncovered no apparent toxicity
The administration of high doses of lipoic acid by injection to rats decreased the activity of two biotin-dependent enzymes by about 30%-35% (122), but it is not known whether oral or intravenous lipoic acid supplementation substantially increases the requirement for biotin in humans (123)
doi:10.1080/00365513.2020.1804610 Kanth VV, Golla JP, Sastry BK, et al
(Thoma et al., 2003)
however, high doses may lead to mild gastrointestinal discomfort in some individuals
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