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The substantial impact of LASSS pre-treatment was more pronouncedly demonstrated by an alternative experiment using the disulfide lipoic acid (LA, containing two sulfur atoms connected by a disulfide bond)

The study evaluated pre-treatment vitamin D levels in samples taken from 1,191 early breast cancer patients prior to chemotherapy and, after accounting for other possible patient differences, looked at whether low vitamin D was associated with development of grade 3 CIPN

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