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The structures were subsequently refined at 2.82 (apo wild type SnCE1), 2.21 (apo SnCE1 C256A) and 1.55 (SnCE1-SUMO1-PA) in REFMAC5 including TLS refinement 120

An important aspect that have emerged is the broad spectrum of effects covered by the angiogenic inhibitors and the diversity in terms of therapeutic response [305]

To achieve the best outcomes, more sessions could be needed for larger or more difficult-to-reach areas

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Although improvements in neonatal care have decreased the impact of early-onset sepsis in term infants, preterm babies remain at high risk for both early-onset and late-onset sepsis and their sequelae