Minoxidil's mechanism a systemic vasodilator with no follicle specificity means side effects can extend well beyond the scalp: unwanted facial hair, scalp irritation, contact dermatitis, and (in rare cases) cardiovascular changes from systemic absorption.6 GHK-Cu, as an endogenous peptide acting locally on the cells where it's applied, has no documented systemic side effects and no withdrawal phenomenon when discontinued
However, an important issue is often overlooked: supplement use
Beyond Weight Loss: Alcohol, Impulsivity, and the Brain Huberman highlighted the neurological effects of GLP-1 receptor agonists beyond metabolism: "Reduced alcohol appetite, reduced impulsivity perhaps
The FDA approved Rybelsus in 2019 and oral Wegovy in 2025 (Rybelsus was rebranded as oral Ozempic in 2026)
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