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234 Dupilumab

Sleep architecture is assessed through patient history or, where available, actigraphy or polysomnography data specifically sleep latency, REM and slow-wave sleep proportions, and sleep fragmentation index

F 4, 74 = 5.475

doi:10.1016/j.neuropharm.2012.08.021 Balda MS, Whitney JA, Flores C, Gonzlez S, Cereijido M, Matter K (1996) Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intermembrane diffusion barrier by expression of a mutant tight junction membrane protein

Over the course of 6 months, patients can expect to lose between 10% to 15% of their body weight, with the most significant results occurring between 12 to 16 weeks of consistent use