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What Testers Think Could Be Improved While Pete did not experience any negative side effects, he does think that some folks may experience bloating or water retention during the loading phase, so be aware of possible temporary weight gain

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If the pancreas gets inflamed, the tissues around the channels can swell making it difficult for those digestive enzymes to get out, causing the pancreas to start digesting itself

This usually settles within a day or two

If switching is not possible or not preferred, a pragmatic approach involves increasing oral progesterone from 100 mg to 200 mg daily for the first 4-6 weeks of semaglutide treatment

[Abstract] Am J Pathol