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Insights from the SUSTAIN 17 trials

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NP cells treated with TNF- showed a significant decrease in matrix synthesis-associated protein levels (COL2A1 and ACAN) and an increase in cellular matrix degradation-associated proteins (ADAMTS5 and MMP3), and these effects were reversed by the addition of glutamine (Fig

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C9orf72 ALS/FTD-associated poly (GR) 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)

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