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While not mandatory, following it is highly recommended
Die-off symptoms can be a more intense version of an infection like a cold or other virus
More specifically, overexpression of insoluble A may drive alterations in gamma oscillations and glutamatergic gene expression in the prefrontal cortex, potentially underlying changes in anxiety-related behaviors (Pervolaraki et al., 2019)
Researchers characterize this as a foundational signaling phase the biochemical groundwork for the more measurable changes that studies report later
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