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Importantly, these effects could be recapitulated in cysteine desulfurase (NFS1) knockdown cells with impaired iron-sulfur cluster synthesis, indicating that phenotypes observed in SLC25A39/40 knockout cells are likely a consequence of an iron-sulfur cluster deficiency (Extended Data Fig

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Other Significant/Specific Causes Constipation: Chronic constipation negatively impacts overall health, including the skin

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Travill CM, Pugh S, Noblr MI

[2] Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH