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Rodbard HW, Bellary S, Hramiak I et al (2019) Greater combined reductions in HbA 1c 1.0% and weight 5.0% with semaglutide versus comparators in type 2 diabetes

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In a phase 2 clinical trial, participants receiving the 12 mg dose lost an average of 24.2% of their body weight over 48 weeks the highest weight loss ever recorded for a pharmaceutical agent in clinical trials

The magnitude of blood pressure reduction varies between agents and individual patient factors

But muscle, if you compare that actually would be even more notable and larger

doi: 10.1007/s11892-016-0751-5 41 TwigGZuckerIAfekACukierman-YaffeTBendorCDDerazneEet al