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gene-expression modulation

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Age, genetics, baseline muscle mass, rate of weight loss, and lifestyle factors all influence the degree to which these changes occur

Orlistat (Xenical, Alli) reduces fat absorption in the gut and is the only effective over-the-counter weight loss pill available, says Johnson-Rabbett, though it can have significant gastrointestinal side effects

These compounds are also not approved by the FDA, so they are not obligated to meet the same level of scrutiny of standards that regulate medications