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According to the hematoxylin and eosin (HE) staining, tartrate-resistant acid phosphatase (TRAP) staining, and Safranin O/Fast green (SO/FG) staining, the ankle joint tissues in the saline group exhibited extensive inflammatory cell infiltration, synovial hyperplasia, severe bone erosion, and cartilage destruction (Fig

[66,67] During melanogenesis, tyrosinase is responsible for the conversion of L-tyrosine to L-DOPA and subsequently to dopa-quinone, then the pathway bifurcates to produce eumelanin or phaeomelanin

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