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Current understanding relies heavily on extrapolation from consistent animal model results and accumulating anecdotal human reports

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Oxidative Medicine and Cellular Longevity, 2016 , 3286365

It also influences metabolism, usually in the liver through a hormone called Insulin-like Growth Factor (IGF-1) and an appetite hormone called gherlin in the stomach.[1]

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Diagnosis of each histopathological change was made using histological classifications for aging mice 33,49,50