2,3-Bisphosphoglycerate (2,3-BPG) is an intermediate metabolite present in high concentrations in RBCs (approximately 5 mM) and is the principal allosteric effector for hemoglobin (that is present at almost the same concentration as a tetramer), decreasing its affinity for oxygen
Action: This long half-life allows it to drive muscle hyperplasia (new cell creation) and hypertrophy (cell size increase) over a sustained period by binding to the IGF-1 Receptor (IGF-1R) with high affinity
Who It Is For Men currently on TRT who want to maximize their results Men over 40 experiencing both testosterone and GH decline Active men on TRT who train intensely and want faster structural tissue recovery Men on TRT who are dealing with joint pain, tendon issues, or chronic inflammation Patients who want a comprehensive hormone and recovery protocol rather than TRT in isolation What to Expect Weeks 1-4: Improved sleep (sermorelin), reduced joint or tendon pain (BPC-157), and enhanced recovery between training sessions
It promotes hair growth and supports overall skin and tissue health, making it an invaluable addition to skincare routines
Updated September 2025
While present in animal products, including meats, fish, shellfish, dairy products, and eggs, it is absent in plant- based foods