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The impurity caused by the interaction between B12 and compounded tirzepatide is concerning because nothing is known about its short- or long-term effects in humans, the potential impact on the drugs interaction with the GLP-1 and GIP receptors, toxicity, immune reactions, or how it is absorbed, distributed, metabolized and eliminated

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A retrospective study of 94 people using compounded semaglutide with cyanocobalamin showed an average loss of 2.7 kg of fat mass and 1.4 kg of lean mass after three months, compared with prospective studies of brand-name semaglutide, which showed approximately 10 kg of fat mass loss at seven months