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In the TRIUMPH-1 trial, the 4 mg dose had a lower discontinuation rate due to adverse events than even placebo, suggesting that lower doses are well-tolerated
thus the TF-dependent pro-thrombotic effect is pronounced (77)
Muscles formed by fast fibres tend to have a lower oxidative capacity, generate considerable energy from glycolysis and high-energy phosphate stores, being susceptible to rapid fatigue
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