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Yes, metformin can make it harder for your body to absorb B12
The NHS advises that taking up to 2mg (2000 micrograms) daily of vitamin B12 supplements is unlikely to cause harm, with no established upper limit in the UK
It works by inhibiting NNMT, an enzyme that regulates cellular energy metabolism and is mostly found in fat tissue
A deficiency of vitamin B12 often occurs when dietary intake is insufficient or when the body has issues with absorbing vitamin B12
Also known as cobalamin, vitamin B12 is a necessary vitamin that aids in many essential body functions
doi:10.1111/1756-185x.14293
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