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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

Xenobiotic metabolism by hepatocytes can occur by phase I (often the cytochrome oxidase series) and phase II reactions (often the formation of the water soluble glucuronide) (Graham and Lake 2008

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10.1038/ncb1005 3 AppasamyR.TanabeM.MuraseN.ZarnegarR.Van ThielD

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