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3.6 MAPKAPK2 overexpression modulates the KEAP1/Nrf2/HO-1 axis under oxidative stress To elucidate the molecular mechanism underlying MAPKAPK2-mediated antioxidant protection, we examined the KEAP1/Nrf2/HO-1 regulatory axis in PIG3V cells upon H 2 O 2 -induced oxidative stress
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