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Porphyria: The use of diclofenac and anti-inflammatory steroids in patients with hepatic porphyria should be avoided
Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%
This helps equalize the pressure inside the vial, facilitating easier withdrawal of the liquid
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The liquid sublingual form also bypasses liver processing and is immediately absorbed into the blood stream
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