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In the laboratory study Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo (Chen and colleagues, Proceedings of the National Academy of Sciences, 2007), pharmacologic ascorbate acted as a prodrug that formed hydrogen peroxide in the extracellular space but not in blooda route-dependent effect that oral dosing did not reproduce

This multi-route evaluation demonstrated that AOD-9604s favorable safety profile was not dependent on a specific delivery method, though bioavailability differed between routes

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Laboratory monitoring may include complete blood counts, comprehensive metabolic panels, and hepatic function tests, though specific monitoring protocols have not been established through clinical trials

Due to its stability and structure, it has become a subject of interest in controlled laboratory investigations