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Yuan H, Li X, Zhang X, Kang R, Tang D (2016) Identification of ACSL4 as a biomarker and contributor of ferroptosis

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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females

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Association between proteomics data and clinical characteristics Proteomics analyses not only identify biomarkers associated with depression but also uncover critical links between these biomarkers and clinical characteristics