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It is absolutely critical
Srinivas, K
[16] [121] Upon leaving the stomach the hydrochloric acid of the chyme is neutralized in the duodenum by bicarbonate, [122] and pancreatic proteases release the vitamin from HC, making it available to be bound by IF, which is a protein secreted by gastric parietal cells in response to the presence of food in the stomach
Feldmesser et al., 1996
Oxylipin metabolism is controlled by mitochondrial beta-oxidation during bacterial inflammation
Youre concerned about side effects and prefer starting with the medication that tends to have slightly milder GI issues
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