Puerarin at 40 mol/L significantly increased the melanin content of human melanocytes by decreasing the phosphorylation of ERK in the cells to promote TRP-1 and MITF expression, which led to an increase in melanin content ( Butin Butin (7, 30, 40-trihydroxydihydroflavone, BUT
& Burgener, K
These effects drive inflammatory processes and nitro-oxidative pathways [100] and the resultant excess of reactive oxygen species may induce oxidative damage, aggravating systemic tissue damage and contributing to more severe COVID-19 [101]
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Moreover, we noted the influence of publication bias in some studies, suggesting a potential bias in the journals selection of articles for publication
Example in development - Triple agonists targeting GLP-1, GIP, and glucagon are in early trials