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Nature (1983) 302(5910):7168

demonstrated no effect of optogenetic or chemogenetic activation of GPR65-positive cells on food intake and only a mild effect via GLP-1R-positive cells 28

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The study reported that once-weekly CagriSema resulted in a significant body weight reduction of 13.7% and a higher percentage of patients achieving an HbA1c level of 6.5% or less, confirming the combination's superior efficacy for both weight loss and glycemic control in this population

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