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This may partly reflect its popularity and widespread use, which increases the total number of adverse event reports

9 Accordingly, much of the field has focused on intracellular determinants of susceptibility, including cellular iron handling, glutathione metabolism, the remodeling of polyunsaturated fatty acid (PUFA)-containing phospholipids, and both glutathione peroxidase 4 (GPX4)-dependent and GPX4-independent antioxidant defense pathways

Chen X, Zhao P, Wang W, Guo L, Pan Q

PMCID: PMC1934514

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Together they are studied in preclinical models for somatotropic-axis signaling, pituitary GH pulse amplification, and IGF-1 pathway research