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It has also been observed a correlation between high levels of GSTP1-1 in the brain and medical intractability, suggesting that the enzyme may contribute to resistance to antiepileptic drug treatment 62

2020;20(1):S610

This means cagrilintide and GLP-1 agonists are not competing for the same mechanism they are engaging the appetite-regulation system through separate but reinforcing pathways, which underpins the rationale for their combination

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