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Key Discovery Milestones With active concentrations in the nanomolar range (10 M) and a safety margin 300-fold above therapeutic doses, GHK-Cu combines potent biological activity with an excellent safety profile established through decades of clinical use and research studies published in peer-reviewed journals like PubMed

411,412,413,414 This effect is mediated by NAD + -dependent PARPs and SIRT1

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(8) These findings underline the complex and multifaceted ways in which DSIP might influence sleep and stress management, although more research is needed to understand its mechanisms of action