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Results Cryo-EM determination of the GLP-1R:G s complex bound by oxyntomodulin and exendin-4 Cryo-EM structures of exendin-4- and oxyntomodulin-bound GLP-1R-G s complexes were determined using established methodology 12,13,14
We aim to compare the effects of once-weekly subcutaneous semaglutide with those of liraglutide or dulaglutide administration in Japanese patients with T2D
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These findings indicate that GLP-1R activation specifically inhibits GSDMD-mediated microglial pyroptosis, a finding consistently replicated in subsequent in vitro experiments (Song et al., 2022)