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In both conformations, the pinane ring of the compound interacts with F324, V469, T471, A481 and L484 in subpocket C (Supplementary Fig

RipAY is a class II enzyme that is found exclusively in these two plant pathogens ( Since its initial identification as a potential regulator of the Escherichia coli cha (Ca 2+ /H + antiporter) operon, which is involved in cation transport ( CHAC1 was identified as an endoplasmic reticulum (ER) stress-responsive gene, which prompted detailed investigations into its molecular structure and functional mechanisms (Zhou, Q

The central mechanism is angiogenesis: the peptide upregulates vascular endothelial growth factor (VEGF) and drives new blood-vessel formation at injury sites, which brings oxygen and nutrients to healing tissue

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Mice metabolize peptides differently than rats

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