Protocol 2: significant weight loss (20-25% body weight) Goal: Substantial weight reduction for health improvement Tirzepatide approach: Full escalation to 10-15 mg Expect to reach target dose by week 17-21 Weight loss at 15 mg: approximately 22.5% at 72 weeks Plateau typically occurs around weeks 60-72 Retatrutide approach: Full escalation to 8-12 mg Expect to reach target dose by week 13-17 Weight loss at 12 mg: 24.2% at 48 weeks, 28.7% at 68 weeks No plateau observed in trial data at 48 or 68 weeks For significant weight loss goals, retatrutide reaches 20%+ body weight reduction faster and ultimately achieves a higher ceiling
Common Reasons Why GLP-1 Treatment May Not Work Several factors can explain why GLP-1 medications may not produce the expected results for some individuals
For instance, in November 2023, Lilly Canada, a medicine company, announced that Mounjaro (tirzepatide) is now available in Canada
It works the same way suppressing appetite, slowing digestion, and improving insulin response even if baseline blood sugar is regular
Dynamic fuel switching in response to environmental stress is a fundamental adaptive strategy that allows organisms to efficiently match energy production to demand
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