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As sitagliptin clearly reduced DPP-4 activity and increased GLP-1 levels in mice after BMT, these findings are consistent with impairment of GLP-1 action by bone marrowderived cells

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3,507 GLP-1RAs reduce liver fat accumulation by activating AMPK, which inhibits fatty acid synthesis enzymes and promotes fatty acid -oxidation, thus diminishing lipid droplet accumulation in hepatocytes

Tier 4: Avoid if possible (highest risk) Cocktails with sugary mixers (margaritas, pina coladas, daiquiris, cosmos)

Open 8 , e250081 (2025)