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IL-4, through the JAK2-STAT6 pathway, reduces MITF and TRP-1 expression in normal human melanocytes (NHM), thereby inhibiting melanin production (Renauld, 2001

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However, this attempt failed and this approach did not prove successful until the introduction of the incretin hormone glucagon-like peptide-1 (GLP-1) as the basis for glucose-lowering therapeutics in type 2 diabetes

This trial demonstrated that an oral formulation of semaglutide can result in double-digit weight loss with a favourable safety and tolerability profile in people with obesity

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It is the first triple-agonist peptide to reach Phase 3 clinical trials, activating GLP-1, GIP, and glucagon receptors simultaneously