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Petersburg Institute of Bioregulation and Gerontology, epithalon is a synthetic tetrapeptide (a sequence of four amino acids) that has been shown to induce telomerase activity and telomere elongation in human somatic cells [1]
Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
As a consequence, the true HR would potentially be more in favor of GLP-1 RAs than the HRs observed in this study
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