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Hepatocyte-specific deletion of hepatocyte nuclear factor-4 in adult mice results in increased hepatocyte proliferation
The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure
Built for long-term cellular resilience and detox balance, not short bursts
Gomez-Zorita et al., 2013
824 weeks depending on baseline metabolic health
Its still widely used today
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