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In SELECT, semaglutide 2.4 mg subcutaneously weekly reduced MACE by 20% (HR 0.80, 95% CI 0.720.90) with a 1.5% absolute risk reduction over a mean follow-up of 39.8 months [3]
The hepatotoxicity of ethanol is primarily from metabolism to acetaldehyde, and by reducing ethanol metabolism from ethanol to acetaldehyde, GLP-1R agonism may be hepatoprotective, independent of a decrease in ethanol consumption 14
For patients with type 2 diabetes , the American Diabetes Association recommends individualized glycemic targets and regular reassessment of pharmacologic therapy
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This could be due to the structural characteristics of tirzepatide, which confer a longer half-life, reducing the impact of decreased drug clearance due to renal impairment, maintaining relatively constant blood concentrations, and ensuring sustained glycemic control
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