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In its first registrational Phase 3 obesity trial (TRIUMPH-1), average weight loss reached 28.3% at 80 weeks and up to 30.3% at 104 weeks in a select extension cohort

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The WHO's December 2025 guidelines define long-term use as continuous treatment for six months or more, often years

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Other factors including lifestyle choices like smoking, drinking, stress, and poor diet can also slow down peptide production

GI side effects like nausea and diarrhea were most common, but these were manageable and resolved over time, researchers said