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Schizophrenia: A meta-analysis of NAC augmentation in schizophrenia found significant improvements in total PANSS scores and negative symptoms (Yolland et al., Aust N Z J Psychiatry, 2020) [75]

Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)

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