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Dysregulation of TNF alpha is involved in the pathogenesis of numerous inflammatory conditions, most notably rheumatoid arthritis, inflammatory bowel disease, psoriasis vulgaris, and psoriatic arthritis

patients with certain metabolic disorders also exhibit marked increases in TMAO levels when supplemented with LC [26]

However, researchers state that their efficacy may be dependent on the patients baseline metabolic dysfunction

Beverly Tchang, MD, an endocrinologist and obesity specialist at NewYork-Presbyterian and Weill Cornell Medicine in New York City, instructs some of her patients to microdose to help balance side effects with weight loss goals

This provides some therapeutic buffer, though effects on blood sugar control and appetite suppression gradually diminish as drug levels decline

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